( 29916050) Opioids alone don't cause serotonin syndrome, but they may promote it in combination with other agents. Opioids (Meperidine, fentanyl, tramadol, dextromethorphan, methadone, oxycodone, tapentadol, levorphanol, pentazocine, pethidine).Ergot derivatives (ergotamine, methylergonovine).Antiemetics ( ondansetron, granisetron, metoclopramide).Antiepileptics (carbamazepine, valproate).Antipsychotics that are strong antagonists at 5-HT2A receptors □ might indirectly activate 5-HT1A receptors and thereby promote serotonin syndrome (e.g., risperdal, olanzapine).MAO inhibitors (especially dangerous including rasagiline and selegiline).Tricyclic and tetracyclic antidepressants (including mirtazapine).SSRIs & SNRIs (including trazodone note fluoxetine's half-life of 1-2 weeks).Medications that cause or promote serotonin syndrome
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